The boxers are scheduled to fight at the AT&T Stadium in Arlington, Texas on 16 November with millions expected to tune in to see what happens.
The sporting event has already been rescheduled once, back in July, due to the 58-year-old ‘thinking he was going to die’.
A recent Netflix documentary about the icon revealed that he suffered a serious ulcer flair-up while on a plane.
He said: “A week and a half ago I was training and I was doing great but then all of a sudden I started feeling tired. I was explaining to my trainer, ‘I don’t know what’s wrong with me’.
“Coming here from Miami on the plane, I went to the bathroom, and I threw up blood. The next thing I know I’m on the floor, I was defecating tar.
“So, I came here, and they found I had a big ulcer, two-and-a-half inches, and it was bleeding. All my friends were calling me like I was dying.”
When the flight was originally rescheduled, Paul said: “When I received the news that he was out and not able to fight, I was just numb, I was just like, ‘f**k’.”
The fight, now rescheduled to this weekend, will only go ahead if Tyson is able to pass two health checks.
He reportedly agreed to the checks months ago, before getting the all clear. He will reportedly have a brain test (EEG) and a heart test (EKG) before being accepted into the ring.
These tests were required by the Texas Department of Licensing and Regulation.
Both Paul and Tyson are expected in the ring on 16 November.